Synthesis of N-(2,8-Dioxo-1-oxaspiro[4.5]deca-6,9-dien-7-yl) Acetamide and Benzamide
نویسندگان
چکیده
The syntheses of two new spirolactones are described. Each compound was obtained as an off-white solid in 66% yields from 4-hydroxy-3-nitrobenzaldehyde.
منابع مشابه
Diastereoselective spiroannulation of phenolic substrates: synthesis of (+/-)-2-tert-butyl-6-methoxy-1-oxaspiro[4,5]deca-6,9-diene-8-one.
The synthesis of a new spiroether is described. The title compound is obtained as a diastereomeric mixture in 45% yield.
متن کاملDocking Studies of Kappa Opioid Receptor Agonists
The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...
متن کاملMethyl 2-(1a,4a-dimethyl-2,8-dioxo-2,3,4,4a,5,6,7,8-octahydro-1aH-1-oxacyclopropa[d]naphthalen-7-yl)acrylate
The title compound, C(16)H(20)O(5), was synthesized from ilicic acid [2-(8-hy-droxy-4a,8-dimethyl-deca-hydro-naphthalen-2-yl)acrylic acid], which was isolated from the chloro-form extract of the aerial part of Inula viscose (L) Aiton [or Dittrichia viscosa- (L) Greuter]. The molecule is built up from two fused six-membered rings, the epoxidized six-membered ring adopts a half-chair conformation...
متن کاملPharmacophore & Docking based combined Insilico study of Kappa Opioid Receptor Agonists
The purpose of the study was to compare the binding energy of pharmacophores of different classes targeting to kappa opioid receptor (KOR) with ketazocine and pentazocine which are having good activity on the KOR. The 3D structure of KOR receptor was built by Homology modeling; pharmacophores were characterized by using Ligand scout. Docking studies for the KOR agonists were performed in Autodo...
متن کاملTandem Prins/pinacol reaction for the synthesis of oxaspiro[4.5]decan-1-one scaffolds.
A novel Lewis acid catalyzed Prins/pinacol cascade process has been developed for the synthesis of 7-substituted-8-oxaspiro[4.5]decan-1-ones in good yields with excellent selectivity. This is the first example of the synthesis of oxaspirocycles from aldehydes and 1-(4-hydroxybut-1-en-2-yl)cyclobutanol through a cascade of Prins/pinacol rearrangement. This method is applicable to a wide range of...
متن کامل